Drug Reconstitution Practice Questions
Random reconstitution problems – concentration after mixing and the volume to draw up – with instant checking, plus ten worked examples across tablets, suspensions and injections.
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Worked practice problems
Problem 1. A 1 g vial is reconstituted to a final volume of 10 mL. The order is 350 mg.
Answer and steps
1 g = 1000 mg. Concentration: 1000 ÷ 10 = 100 mg/mL. Volume: 350 ÷ 100 = 3.5 mL.
Problem 2. A 500 mg vial is reconstituted to a final volume of 4 mL. The order is 187.5 mg.
Answer and steps
500 ÷ 4 = 125 mg/mL. 187.5 ÷ 125 = 1.5 mL.
Problem 3. A 2 g vial is reconstituted to 8 mL. The order is 750 mg.
Answer and steps
2000 ÷ 8 = 250 mg/mL. 750 ÷ 250 = 3 mL.
Problem 4. Tablets on hand are 250 mg. The order is 0.5 g.
Answer and steps
0.5 g = 500 mg. 500 ÷ 250 = 2 tablets.
Problem 5. A suspension is 125 mg/5 mL. The order is 200 mg.
Answer and steps
200 × 5 ÷ 125 = 8 mL.
Problem 6. The order is 0.25 mg. Tablets on hand are 125 mcg.
Answer and steps
0.25 mg = 250 mcg. 250 ÷ 125 = 2 tablets.
Problem 7. A vial contains 40 mg/mL. The order is 25 mg.
Answer and steps
25 ÷ 40 = 0.625 → 0.63 mL (rounded to hundredths for a 1 mL syringe).
Problem 8. Heparin is available 10,000 units/mL. The order is 7,500 units.
Answer and steps
7500 ÷ 10000 = 0.75 mL.
Problem 9. A 2 g vial is reconstituted to 10 mL. The order is 1.2 g.
Answer and steps
2000 ÷ 10 = 200 mg/mL. 1200 ÷ 200 = 6 mL.
Problem 10. An ampoule contains 300 mg in 2 mL. The order is 600 mg.
Answer and steps
300 ÷ 2 = 150 mg/mL. 600 ÷ 150 = 4 mL.
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Educational practice only – values are invented for training and are not clinical recommendations. Reviewed 2026-08-23.